NEI funded research within the Atlanta Vision Research Community aims to elucidate disease mechanisms and develop effective treatments for blinding conditions. Module 3 advances this goal by supporting studies that use cellular and ex vivo ocular tissue samples to investigate the physiology and pathophysiology of vision and to develop therapeutic approaches for a broad range of ophthalmic diseases. This work complements imaging based studies supported by Module 1 and in vivo animal research supported by Module 2.

Module 3 builds upon and significantly enhances established capabilities within the P30, including histology, microscopy, and cell culture, as well as stem cell differentiation and handling. The module also expands support for mass spectrometry based analyses and high content, cell based screening assays. Together, these services enhance molecular and functional phenotyping of cells and ex vivo tissues and support mechanistic and translational studies across conditions such as glaucoma, myopia, inherited retinal degenerations, diabetic retinopathy, retinal pigment epithelium dysfunction, and age related macular degeneration. By providing shared equipment, technical expertise, and collaborative support, Module 3 strengthens research impact, facilitates collaboration across AVRC institutions, and accelerates the discovery of novel therapeutic strategies.